Helga Von Guggen is a rogue fashion designer and one of the show's recurring villains. She has a bodyguard, Trode, to do her bidding.
In "Wild Style", Trode met the spies while they were investigating the mass disappearances of cruise ships along with their crews and passengers. Helga was the mastermind behind the abductions, and instructed Trode to infect one of the spies with her mutation serum through the use of a dart, resulting in Clover being mutated into a catgirl. At Helga's hideout, Helga revealed to the spies that she was using the serum to turn humans into animal creatures in order to produce instant-fitting pelt coats. Ultimately, Helga fell victim to her own mutation serum and transformed into a massive Chimaera mutant monster, and was defeated and captured by the girls.
In "Fashion Faux Pas", Helga returned (in her normal state) with a scheme to use Mystique fashion clothes to strangle people to death. At her hideout, she told the spies her plan, and ordered Trode to keep an eye on them. In the end, she was turned in and captured again. It is never explained how she returned to normal in this episode.
She later appears again in Season 4 as a member of the LAMOS, having herself been disposed of Trode, whom she deemed to be too incompetent. In "Evil Jerry" Helga was arrested, but she returned (presumably having escaped) in "Like, So Totally Not Spies", and at the end of that episode, Helga and all the other members of LAMOS were arrested.
In "Like, So Totally Not Spies", it is shown that Helga is allergic to shrimp and shellfish.
- Helga translates to "holy" or "blessed". This is how she views her fashion design skills.